Organocatalysts of oxidative protein folding inspired by protein disulfide isomerase.
نویسندگان
چکیده
Organocatalysts derived from diethylenetriamine effect the rapid isomerization of non-native protein disulfide bonds to native ones. These catalysts contain a pendant hydrophobic moiety to encourage interaction with the non-native state, and two thiol groups with low pKa values that form a disulfide bond with a high E°' value.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 12 43 شماره
صفحات -
تاریخ انتشار 2014